Choosing Binders for Detox – Direct Elimination Method Series Part 3

In this article, I will go over how to choose toxin binders for the Direct Elimination Method. Please see part 1 of the Direct Elimination Method series for an explanation of the method, and part 2 for instructions on how to perform a toxin binder enema.


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What binder(s) do I use?

Your choice of binders will depend on the toxins most present in your body. Each binder is effective for certain types of toxins. You may even require different binders, to address different toxins.

How do you figure this out? Consider your known toxic exposures and history. For example, are you just coming out of a moldy water-damaged home? Do you live near a farm or golf course with heavy herbicide/pesticide usage?.

Certain sets of symptoms also suggest certain toxic exposures. However, that is a complicated subject that justifies additional articles. A qualified healthcare practitioner trained in functional or environmental medicine can work with you to identify which toxins are most present in your body and the best binders to use. Click the links for practitioner finder maps. Later parts of the Direct Elimination Method series will go over specific applications for certain binders and toxins.

The most important thing is that the binder be non-absorbed. 

This means the binder should not be able to cross the tissues that line internal body cavities (such as the rectum). In contrast, absorbed binders can cross these linings, and enter the blood. 

What’s wrong with absorbed binders?

After all, if they enter the blood, they should be more effective, right? The problem is – absorbed binders have trouble leaving the body. They stay in the blood, circulating in the body. This can lead to two things:

  1. Toxin redistribution: After entering the blood, absorbed binders can move their bound toxins around. They can eventually let go of these toxins. This causes redistribution in the body tissues. If this happens, you’re no better off than before in terms of reducing toxic load. Redistribution can actually cause additional symptoms.
  2. Organ stress: Certain absorbed binders require processing by detox organs such as the liver and kidneys before the binder and toxin can be excreted. Remember, we are trying to minimize the workload on these organs.

Meanwhile, non-absorbed binders in the rectum are still in contact with the body’s whole supply of circulating blood. The binders capture toxins in the blood while remaining in the rectum. Then once the rectum empties, both the binders and the toxins instantly leave. There’s less risk of redistribution or organ stress.

What are common absorbed binders to avoid?

A note on zeolite

*I mention Biopure Zeobind because it’s what I use and is easily available in the United States. But the key is that the zeolite be based on clinoptilolite (a zeolite subtype). Other good brands include Ki science (United Kingdom), ZeolithMED (UK), and BioPractica Toxaprevent (Australia). 


Toxin categories and non-absorbed binders to address them:

I find that this order of toxin types has been the order in which my body started eliminating different toxins. High mold toxicity impairs elimination of heavy metals, and so on.

Within each category I have listed binders from most to least effective for that type of toxin, based on my own and others’ experience. I have also included links to published scientific papers discussing these binders.

Mold toxins

*Cholestyramine is a prescription medication. Please consult with your physician if you wish to use this.

Chemical toxins

Heavy metals


Herbicides/pesticides (including glyphosate)


What if I don’t know what types of toxins I have?

Since the activated charcoal and Zeobind are the most broad spectrum binders available, it may be a good idea to start out with those. Try each one out and see how you feel. Ultra Binder is another good broad spectrum binder but is more expensive.

Can I mix binders?

It’s best to avoid mixing different binder types. Different binders may have different chemical charges, and bind to each other instead of to toxins. But I and others have found that it is okay to mix activated charcoal and zeolite without them interfering.

How much binders do I use?

There’s no single answer to this question. Experiment with what works best for you. I find that one half to one dose that you would normally take orally (what’s on the bottle label) is a good starting point, but your experiences may vary. It is better to under-dose and have to do another enema, than to overdose and cause toxin mobilization (which could aggravate symptoms). In part 4, I will explain this concept in more detail.

8 Replies to “Choosing Binders for Detox – Direct Elimination Method Series Part 3”

    1. Hi Jesse,

      The label photos on Amazon don’t give much info on this product. I’d want to know if it is clinoptilolite or another form of zeolite. Also based on the description it seems like it can be absorbed into the blood which is not as desirable for the DE method.

      Sorry for the late reply. I took some time away from blogging due to school responsibilities.

  1. I really enjoy reading your articles. They are an easy read, very thorough with a pinch of humor. Please keep up the great work!!

  2. Nice blog/website. I just made one myself and will be talking about mold and my journey on getting better from it.
    I just wanted to say that I think you should add Alpha Lipooc Acid to the list of binders NOT to use. It would probably burn badly anyways. Lol

    1. Good call Nicole – ALA does get absorbed into the blood and can redistribute metals. But I like to use a small amount (~1/50 of a 100 mg capsule) in enemas with chelators to help get metals out of the brain. RLA (the active enantiomer form of ALA) does not burn, but ALA that includes both RLA and SLA does.

      1. Andrew could you tell me what brand of RLA you use? I do not see one that does not add the SLA to the formula. I would like to use it for the DE Method. Thank you for all that you have shared here. The DE Method is helping me tremendously.

        1. Hello Ellyse,

          I’m glad to hear the DE method is helping you! I use Thorne’s RLA product (affiliate link):

          This one does not have any SLA. One time I ordered their ALA product by mistake, which has both RLA and SLA.


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